FLAP Inhibitors: Preclinical and Clinical Evidence
Notably, all memory tests– water mazes, fear conditioning, field excitatory postsynaptic potentials, and radial water mazes– except paired-pulse ratios were positive (paired-pulse ratios had no significant results). Related functional tests were positive only with sustained doses of FLAP Inhibitors, while one study found negative results in old mice (but no significant results in adult mice). Interestingly, one forced-swim-away found increased climbing behaviors in the FLAP Inhibitor group, which is similar to what has been found for antidepressants.