Study chaStudy chaInterventInterventPatient CPatient CTreatmentTreatmentOutcomesOutcomesStudy typStudy typDisease cDisease cFLAP inhiFLAP inhiComparatoComparatoSexSexSpeciesSpeciesAge groupAge groupFLAP inhiFLAP inhiFunctionFunctionTissue meTissue meSafety evSafety evAnimal stAnimal stMK-886MK-886Sham/placSham/placMouseMouseAdultAdultMemory anMemory anOther funOther funAnxietyAnxietyMicrogliaMicrogliaTissue inTissue inEdema/sweEdema/sweGross patGross patmeasures measures Tissue leTissue leOther tisOther tisTau proteTau proteAmyloid bAmyloid bComparatiComparatiForced SwForced SwCD43+ celCD43+ celCD68+ celCD68+ celCOX-2 celCOX-2 celTissue LTTissue LTphosphoryphosphorysoluble Asoluble AWestern BWestern B
Tag Details
5/17 (29.4%) of studies are associated with this tag. 5/17 (29.4%) of studies are associated with this tag & its descendants.
Associated StudiesSelected Tags:
Microglia infiltration
BPP-1001 (MK-591)
Title
Author
5-lipoxygenase activating protein reduction ameliorates cognitive deficit, synaptic dysfunction, and neuropathology in a mouse model of Alzheimer's disease.
Giannopoulos
Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model.
Chu
Prolonged neuroinflammation after a single closed head injury is mediated by the 5-lipoxygenase pathway and does not require peripheral immune cell infiltration
Corser-Jensen
3 studies
1
FLAP Inhibitors: Preclinical and Clinical Evidence
Notably, all memory tests– water mazes, fear conditioning, field excitatory postsynaptic potentials, and radial water mazes– except paired-pulse ratios were positive (paired-pulse ratios had no significant results). Related functional tests were positive only with sustained doses of FLAP Inhibitors, while one study found negative results in old mice (but no significant results in adult mice). Interestingly, one forced-swim-away found increased climbing behaviors in the FLAP Inhibitor group, which is similar to what has been found for antidepressants.
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