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Qualitative
Quantitative
PRISMA
Fixed Effects
Random Effects
Summary
Distribution
NMA
Table
Visual
Intervention
Outcome
Mortality at 90D
(n/N)
%
[CI]
Outcome
Neurological Outcome (mRS 0-2 at 90D)
(n/N)
%
[CI]
Outcome
Symptomatic Intracranial Hemorrhage (sICH)
(n/N)
%
[CI]
Interventions
1297/7320
17.8%
[16.4%, 19.4%]
3219/7283
44.4%
[41.1%, 47.7%]
358/7203
5.1%
[4.4%, 5.8%]
Mechanical thrombectomy
676/3633
18.9%
[16.9%, 21.1%]
1674/3607
47.0%
[44.0%, 50.0%]
181/3614
5.4%
[4.7%, 6.3%]
Thrombolysis/Medical therapy
264/1373
19.5%
[16.4%, 23.0%]
399/1365
30.8%
[24.8%, 37.5%]
46/1336
4.0%
[3.0%, 5.3%]
Mechanical Thrombectomy + IVT
357/2314
14.7%
[12.3%, 17.4%]
1146/2311
52.2%
[46.2%, 58.2%]
131/2253
5.7%
[4.1%, 7.8%]
Mortality at 90D
Neurological Outcome (mRS 0-2 at 90D)
Symptomatic Intracranial Hemorrhage (sICH)
Male Sex
Parent Artery Location
mTICI 2b/3 and eTICI 2b/3
Age (Median) (years)
Age (Mean) (years)
Onset-to-alteplase
Onset-to-groin puncture
TICI 3 or mTICI 3 or eTICI 3
Embolization to New Territory (ENT)
Achieved Early Neurological Improvement?
mTICI 2c/3 or eTICI 2c/3
Distal emboli
TICI 2b/3
Admission-to-needle
Number of passes (Median)
FPE mTICI 2b/3 or eTICI 2b/3
Needle-to-puncture
Number of Passes (Mean)
TICI 2c/3
FPE TICI 3
FPE mTICI 2c/3 or FPE eTICI 2c/3
FPE TICI 2b/3
Angiographic Outcomes
Mortality at 90D
Neurological Outcome (mRS 0-2 at 90D)
Symptomatic Intracranial Hemorrhage (sICH)
Male Sex
Parent Artery Location
mTICI 2b/3 and eTICI 2b/3
Age (Median) (years)
Age (Mean) (years)
Onset-to-alteplase
Onset-to-groin puncture
TICI 3 or mTICI 3 or eTICI 3
Embolization to New Territory (ENT)
Achieved Early Neurological Improvement?
mTICI 2c/3 or eTICI 2c/3
Distal emboli
TICI 2b/3
Admission-to-needle
Number of passes (Median)
FPE mTICI 2b/3 or eTICI 2b/3
Needle-to-puncture
Number of Passes (Mean)
TICI 2c/3
FPE TICI 3
FPE mTICI 2c/3 or FPE eTICI 2c/3
FPE TICI 2b/3
Angiographic Outcomes
Mortality at 90D
Neurological Outcome (mRS 0-2 at 90D)
Symptomatic Intracranial Hemorrhage (sICH)
Male Sex
Parent Artery Location
mTICI 2b/3 and eTICI 2b/3
Age (Median) (years)
Age (Mean) (years)
Onset-to-alteplase
Onset-to-groin puncture
TICI 3 or mTICI 3 or eTICI 3
Embolization to New Territory (ENT)
Achieved Early Neurological Improvement?
mTICI 2c/3 or eTICI 2c/3
Distal emboli
TICI 2b/3
Admission-to-needle
Number of passes (Median)
FPE mTICI 2b/3 or eTICI 2b/3
Needle-to-puncture
Number of Passes (Mean)
TICI 2c/3
FPE TICI 3
FPE mTICI 2c/3 or FPE eTICI 2c/3
FPE TICI 2b/3
Angiographic Outcomes