Bioscience Pharma Project 2 leukotriene signaling in neuroinflammation SLR
Study characteriStudy characteriAssociationsAssociationsModelModelLevel of evidencLevel of evidencLeukotrienes andLeukotrienes andLeukotrienes andLeukotrienes andLeukotrienes andLeukotrienes andNeuroinflammatioNeuroinflammatioPatientsPatientsHuman cell line-Human cell line-Primary human cePrimary human ceLevel 2b (non-raLevel 2b (non-raLevel 3b (retrosLevel 3b (retrosLevel 5 (expert Level 5 (expert Positive LeukotrPositive LeukotrNegative leukotrNegative leukotrNeutral leukotriNeutral leukotriPositive LeukotrPositive LeukotrNegative LeukotrNegative LeukotrNeutral LeukotriNeutral LeukotriPositive LeukotrPositive LeukotrPositive NeuroinPositive Neuroin
Tag Details
Tag Name:
42
Study characteristics
Model
Patients
Human cell line- standard culture
Primary human cells
Human cell line- 3D culture
Cadaver
Human cell lines- co-culture model
Level of evidence
Level 1a (meta-analysis)
Level 1b (SLR w/out MA)
Level 2a (RCT)
Level 2b (non-randomized prospective comparative)
Level 3a (prospective non-comparative)
Level 3b (retrospective comparative)
Level 4 (case series or case report)
Level 5 (expert opinions and pre-clinical research)
Associations
Leukotrienes and neuroinflammation
Positive Leukotrienes vs Neuroinflammation
Negative leukotrienes vs neuroinflammation
Neutral leukotrienes vs neuroinflammation
Leukotrienes and neurodegeneration
Positive Leukotrienes vs neurodegeneration
Negative Leukotrienes vs neurodegeneration
Neutral Leukotrienes vs neurodegeneration
Leukotrienes and microglia
Positive Leukotrienes vs microglia
Negative Leukotrienes vs microglia
Neutral Leukotrienes vs microglia
Microglia and neuroinflammation
Positive Microglia vs neuroinflammation
Negative Microglia vs neuroinflammation
Neutral Microglia vs neuroinflammation
Microglia and neurodegeneration
Positive Microglia vs neurodegeneration
Negative Microglia vs neurodegeneration
Neutral Microglia vs neurodegeneration
Neuroinflammation and neurodegeneration
Positive Neuroinflammation vs neurodegeneration
Negative Neuroinflammation vs neurodegeneration
Neutral Neuroinflammation vs neurodegeneration
Frequently Co-occurring Tags:
Associated StudiesSelected Tags:
Title
Author
Protection of dopaminergic neurons by 5-lipoxygenase inhibitor.
Kang
Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP.
Klegeris
Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity.
Klegeris
Increased leukotriene C4 and vasogenic edema surrounding brain tumors in humans.
Black
Leukotriene production by human glia.
Shepard
In vitro study of mediators of inflammation in multiple sclerosis.
Merrill
Production of and response to interleukin 1 by cloned human oligodendroglioma cell lines.
Merrill
Effect of calcium ionophore A23187 and of leukotrienes B4 and C4 on the adherence of mononuclear leucocytes in multiple sclerosis.
Mayer
Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury.
Westcott
Leukotrienes B4 and C4 in MS.
Prosiegel
Leukotriene C4 contents, synthase and catabolic activity in human meningiomas.
Inamura
Leukotrienes in the cerebrospinal fluid of multiple sclerosis patients.
Neu
Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: evidence for the expression of a multitranscript family.
Boado
Immunoreactive leukotriene C4 levels in CSF of MS patients.
Haupts
Mediator release in cerebrospinal fluid of human immunodeficiency virus-positive patients with central nervous system involvement.
Froldi
Role of platelet-activating factor in aggregation of leukocytes and platelets in cerebral ischemia.
Uchiyama
"Ex vivo" release of eicosanoid from human brain tissue: its relevance in the development of brain edema.
Gaetani
Cerebrospinal fluid eicosanoid levels: endogenous PGD2 and LTC4 synthesis by antigen-presenting cells that migrate to the central nervous system.
Dore-Duffy
Leukotriene B4 and C4 in cerebrospinal fluid from children with meningitis and febrile seizures.
Matsuo
Leukotriene B4 as a marker of cerebral dysfunction.
Kendall
Arachidonate metabolites affect the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein.
Kinouchi
LTB4 and LTC4 are absent in the cerebrospinal fluid of human immunodeficiency virus type 1-seropositive persons with toxoplasmic encephalitis: evidence for inhibition of 5-lipoxygenase by Toxoplasma gondii.
Mayatepek
Cysteinyl-leukotriene levels in intracerebral hemorrhage: an edema-promoting factor?
Winking
Cerebrospinal fluid concentrations of leukotriene B4 in bacterial meningitis.
Santer
Expression of cysteinyl leukotriene receptor 1 in human traumatic brain injury and brain tumors.
Zhang
Cysteinyl-leukotrienes receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl-leukotrienes.
Di Gennaro
Analysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways.
Allen
A comparative study on the expression of cyclooxygenase and 5-lipoxygenase during cerebral ischemia in humans.
Tomimoto
Leukotrienes in patients with clinically active multiple sclerosis.
Neu
Glutathione homeostasis and leukotriene-induced permeability in human blood-brain barrier endothelial cells subjected to in vitro ischemia.
Muruganandam
Defective metabolism of leukotriene B4 in the Sjögren-Larsson syndrome.
Willemsen
Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations.
Bevan
5-Lipoxygenase in the Prefrontal Cortex of Suicide Victims.
Uz
Role of TLR4 polymorphisms in inflammatory responses: implications for unsuccessful aging.
Balistreri
The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor.
Ciana
Expression patterns of 5-lipoxygenase in human brain with traumatic injury and astrocytoma.
Zhang
Distribution of cysteinyl leukotriene receptor 2 in human traumatic brain injury and brain tumors.
Hu
Signaling pathways in the activation of mast cells cocultured with astrocytes and colocalization of both cells in experimental allergic encephalomyelitis.
Kim
Hypoxia-mediated expression of 5-lipoxygenase-activating protein involves HIF-1alpha and NF-kappaB and microRNAs 135a and 199a-5p.
Gonsalves
The Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene promoter is not associated with late onset Alzheimer disease.
Alvarez
Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1/fractalkine-mediated transmigration of HIV-1-infected CD4⁺ T cells across an in vitro blood-brain barrier model.
Bertin
Does GRK-β arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways?
Daniele
Involvement of 5-lipoxygenase in Alzheimer's disease: a role for DNA methylation.
Di Francesco
Proresolution lipid mediators in multiple sclerosis - differential, disease severity-dependent synthesis - a clinical pilot trial.
Prüss
Cysteinyl Leukotriene Receptor Antagonists Inhibit Migration, Invasion, and Expression of MMP-2/9 in Human Glioblastoma.
Piromkraipak
Case Series Using Montelukast in Patients with Memory Loss and Dementia.
Rozin
Leukotriene-mediated neuroinflammation, toxic brain damage, and neurodegeneration in acute methanol poisoning.
Zakharov
Cysteinyl leukotriene correlated with 8-isoprostane levels as predictive biomarkers for sensory dysfunction in autism.
Qasem
Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index.
Šerý
Inflammatory Eicosanoids Increase Amyloid Precursor Protein Expression via Activation of Multiple Neuronal Receptors.
Herbst-Robinson
In vitro cytotoxicity of montelukast in HAPI and SH-SY5Y cells.
Tseng
Receptors for pro-resolving mediators are increased in Alzheimer's disease brain.
Emre
Metabolic Alterations in the Outer Membrane Vesicles of Patients with Alzheimer's Disease: An LC-MS/MS-based Metabolomics Analysis.
Wei
Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells.
Panossian
Prescription database analyses indicates that the asthma medicine montelukast might protect against dementia: a hypothesis to be verified.
Grinde
Plasma Lipid Mediators Associate With Clinical Outcome After Successful Endovascular Thrombectomy in Patients With Acute Ischemic Stroke.
Hao
Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4.
Wang
Leukotriene Receptor Antagonist Use and Dementia Risk in Patients With Asthma: A Retrospective Cohort Study.
Ishikura
Differential Lipid Mediator Involvement in the Different Forms of Genetic Frontotemporal Dementia: Novel Insights into Neuroinflammation.
Sogorb-Esteve
Leukotriene receptor antagonist use and cognitive decline in normal cognition, mild cognitive impairment, and Alzheimer's dementia.
Xiong
Risk of Neuropsychiatric Diseases According to the Use of a Leukotriene Receptor Antagonist in Middle-Aged and Older Adults with Asthma: A Nationwide Population-Based Study Using Health Claims Data in Korea.
Shim
Cognitive Effects of Montelukast: A Pharmaco-EEG Study.
Schwimmbeck
Plasma Resolvin D2 to Leukotriene B4 Ratio Is Reduced in Diabetic Patients with Ischemic Stroke and Related to Prognosis.
Miao
A possible effect of montelukast on neurological aging examined by the use of register data.
Grinde
64 studies
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